2011-01-19 08:39:04
By Matthew Lasar | Last updated about 18 hours ago
An "outburst of the soul," the composer Frederick Delius called music. The sounds associated with the form produce "a kind of pleasure which human nature cannot do without," observed Confucius. It is the art "which is most nigh to tears and memory," noted the writer Oscar Wilde.
It turns out that these guys were more on target than we thought. Our experience of the music we love stimulates the pleasure chemical dopamine in our brain, concludes a new study produced by a slew of scholars at McGill University. The researchers followed the brain patterns of test subjects with MRI imaging, and identified dopamine streaming into the striatum region of their forebrains "at peak emotional arousal during music listening."
Not only that, but the scientists noticed that various parts of the striatum responded to the dopamine rush differently. The caudate was more involved during the expectation of some really nice musical excerpt, and the nucleus accumbens took the lead during "the experience of peak emotional responses to music."
In other words, just the anticipation our favorite passage stimulates the production of dopamine. "Our results help to explain why music is of such high value across all human societies," the writers conclude.
Chills and thrills
To learn more about the music/brain/stimulation process, the McGill researchers followed subjects through the 'chills' or 'musical frisson' response moment. You may have thought that chills were just a subjective concept, but that isn't the case. They involve a "clear and discrete pattern of autonomic nervous system (ANS) arousal," the experimenters say, which facilitate "objective verification through psychophysiological measurements."
Bottom line: the chills moment "can be used to objectively index pleasure." So these scientists rounded up a cohort of people who had a proven record of getting the "verifiable chills" when listening to their favorite songs.
It took a while to find these folks. 217 people responded to an advertisement looking for chill-susceptible music lovers. Each candidate provided ten pieces of instrumental music that set them off in some way. The genres included tango, techno, punk, rock, electronica, jazz, folk, and classical. They then filled out a questionnaire designed to make sure their chills were authentic, and went through a mental illness screening session.
Degrees of pleasure
The process produced a cohort of 10 subjects for the actual experiment, who were scanned over two sessions. The participants listened to music that they experienced as pleasurable or to which they felt neutral. They also kept track of their chills themselves, including the "number of chills, intensity of chills and degree of pleasure experienced from each excerpt."
Nature neuroscience
Meanwhile these frisson seekers were MRI scanned during the listening experience, and images that correlated with chill laden moments were examined.
"We found that hemodynamic activity in the regions showing dopamine release was not constant throughout the [musical] excerpt, but was restricted to moments before and during chills and, critically, was anatomically distinct," the researchers note.
The McGill group says that this experiment is "the first direct evidence that the intense pleasure experienced when listening to music is associated with dopamine activity in the mesolimbic reward system, including both dorsal and ventral striatum."
Thus dopamine "is pivotal for establishing and maintaining behavior," the researchers conclude:
If music-induced emotional states can lead to dopamine release, as our findings indicate, it may begin to explain why musical experiences are so valued. These results further speak to why music can be effectively used in rituals, marketing or film to manipulate hedonic states. Our findings provide neurochemical evidence that intense emotional responses to music involve ancient reward circuitry and serve as a starting point for more detailed investigations of the biological substrates that underlie abstract forms of pleasure.
It also may explain why, as Oscar Wilde suggested, we experience bursts of pleasant recollection while listening to the music that we enjoy. As studies of nicotine use show, the cigarette induced release of dopamine stimulates the remembrance of things past.
Nature Neuroscience, 2010. DOI
Hair splitting time....
I don't like the use of the word "intoxicating" in this sense, because it technically means the ingestion of a foreign (or TOXIC) substance to give one a feeling of euphoria. Music is a non-physical way to get your body to release dopamine.
Similarly I don't sex would be considered "intoxication" either.
To further and clarify some more on your point:
1. The comparison to chemicals is misleading. There are some chemicals which are simply the brain's normal signals for stuff like "I like this", "this is fun", or basically, "ok, this is worth concentrating on, please continue doing it."
Some drugs mimic the effect of such normal brain signals, by binding to the same receptors. E.g., THC binds to the same receptors as the canabinoids in the brain, so it creates the same euphoria, without it being actually a normal signal released by the brain. (Whereas nicotine merely inhibits the production of MAO-B, an enzime which neutralizes those canabinoids, so it makes you higher by prolonging the effect of the natural ones.)
So basically it's a signal as normal as, dunno, the interrupts in a computer. You can probably find a reason to say it's wrong to simulate interrupts that never happened as part of the normal operation (e.g., wiring a front switch to the NMI trace on the mobo), but railing against a situation where they happened as intended (as this or the "OMG, games produce dopamine" hysteria) is fucking stupid.
2. Dopamine is _not_ a reward signal, so it doesn't even produce such an euphoria.
Dopamine is a motivation signal. Remember when I said that some signals basically say, "ok, this is worth concentrating on, please continue doing it"? That's what dopamine does.
Just about anything that is interesting, captivating or fun by itself is producing dopamine. It's just the brain's way of signalling, "heeyy, I like this! please continue this or stay in the current situation, as apropriate."
Even though dopamine does fire up when an unexpected reward happens (as you'd expect), and is a part of the reward and reinforcement functions, it is not itself a reward signal. It doesn't even seem to play any role in perceiving pleasure.
3. A lot of bullshit around dopamine revolves around its use by the brain in such stuff as sex, or that some stimulants like cocaine also increase dopamine, or that very high levels are associated with manias and psychosis. You just need to drop a mention of one or more of those, and everyone is already ready to lap up "OMG, addiction" bullshit.
In reality that's not very surprising. That sex would also fire up a signal that says "don't stop" when that's a reproduction (hence, natural selection) advantage, is actually as expected as it gets. If the animal were likely to just stop in the middle of sex and go "you know, this is actually quite boring, I'll go pounce on something instead", you'd soon have an evolutionary dead end. (Cue "you've met my ex?" wisecracks;) That it would fire up in conjunction with artificial reward signals, when its normal function _is_ to signal "ok, keep doing whatever gave you the reward", is again rather mundane, and rather uninteresting for its use the rest of the time. And that an abnormal level of it would lead to abnormal effects, again, is actually kind of the normal state for any hormone in the body.
4. But at the end of the day, the fact still remains that it's a signal involved in desire/drive/motivation, and in acknowledging reward/pleasure. Whether you actually subscribe to the school of thought that it does or doesn't take part in actually experiencing that pleasure, the fact remains something has to already be pleasant or interesting to cause a dopamine shot.
That some music you like or a video game or watching Star Trek or really whatever enjoyable activity produces a dopamine shot, just says that you do like it.
Just about the only kind of life that would be free from such "intoxication" would be to never experience anything pleasant or any kind of drive/desire. Also, you'd probably have Parkinson. It's not the kind of existence almost anyone actually has, nor the kind of existence anyone would want.
Well, except if it's those evil music/comics/games addicts. Then their having an existence which includes any fun is obviously eeeevil.