See the strack trace present in this page:
https://ci.genenetwork.org/jobs/genenetwork2/214
The function decorated with `@app.before_requests` is called before every request, even ones retrieving static files like CSS and JS files. This executes the `sqlalchemy.create_engine(...)' statement many times for each page.
I started by checking whether the request is to a *static* or *js* endpoint, and if it is, we do not bother trying to create the engine in that case.
This does not resolve the issue per-se, but it does reduce a lot of the noise when logging.
We have not been able to reproduce this issue for the last few months. I am closing it for now, but we may reopen it if it recurs.