To the brain the pain of rejection really hurts

By Randolph E. Schmid, Ap Science Writer Mon Mar 28, 5:48 pm ET

WASHINGTON The pain of rejection is more than just a figure of speech.

The regions of the brain that respond to physical pain overlap with those that

react to social rejection, according to a new study that used brain imaging on

people involved in romantic breakups.

"These results give new meaning to the idea that rejection `hurts,'" wrote

psychology professor Ethan Kross of the University of Michigan and his

colleagues. Their findings are reported in Tuesday's edition of Proceedings of

the National Academy of Sciences.

Co-author Edward Smith of Columbia University explained that the research shows

that psychological or social events can affect regions of the brain that

scientists thought were dedicated to physical pain.

In a way, we're saying "it's not a metaphor," Smith said in a telephone

interview.

The study involved 40 volunteers who went through an unwanted romantic break-up

in the previous six months and who said thinking about the break-up caused them

to feel intensely rejected.

Functional MRI's were used to study their brains in four situations: When

viewing a photo of the ex-partner and thinking about the break-up; when viewing

a photo of a friend and thinking of a positive experience with that person;

when a device placed on their arm produced a gentle, comforting warmth, and

when that device became hot enough to cause pain, though not physical damage.

The two negative situations thinking about the loss of a partner and the burn

caused response in the overlapping parts of the brain, the study found.

Previous studies had not shown a relationship between physical and emotional

pain, but those had used a less dramatic event, such as simply being told

someone doesn't like you, Smith said.

In this case, the volunteers were people who had actually been rejected and

were still feeling it, he said.

There is evidence that emotional stress, such as the loss of a loved one, can

affect people physically, and Smith said studies like this may help researchers

devise ways to aid people who are sensitive to loss or rejection.

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Online: http://www.pnas.org