oopsy mother fucking doopsy
for epilepsy: either want to decrease glutamate which is excitation or increase gaba which is inhibition
don't worry abotu drug understand concept; want glutamate blocker
or gaba agonist
takes longer to regenerate a neuropeptide
6:24
nitric oxide synthase makes nitric oxide
heme oxidase makes co
gc makes cgmp which has effects on cell
don't know mech
both are good vasodilators
fuck i'm wasted rn lmao i came an hour late because it was set an hour early today ahahahahaahah
co does vasodilation and v inflammation; not really understood
anatomy of eye in lab; probably won't ask about it tho
myopia: focuses too close
hyperopia: behind retina
astigmatism: misshapen
presbyopia: won't bend
photoreceptors in back b/c need to be perfused
circadian rhythm:
melatonin lowest during day; highest during night
few of ganglia do melanopsin; light --> scn --| pineal --> melatonin
pupillary reflex [11:00]
edinger-westphal nucleus --> cn iii --> pupil
cones most prominent by fovea
rods around that
fovea moves all the stuff in front of photoreceptors out of way and the ganglia and stuff
optic disk has no fucking shit bla fuck
rods longer and have more photo pigment
i don't think i've been using headers thus far lmao oops
i'm like raelly seriously drunk now but nobody is catching on as far as i can tell
i'm drinking jack directly from my travel coffee mug
someone else came in late which is why i didn't just leave; he basically just restarted the entire review bc the other people who came on time where done
gα subunit --> pde --| cgmp --> channel --> depol
so gα subunit hyperpolarizes the cell
need to convert trans to cis back to reprime the rhodopsin
need to know abc casette; transporter for retinal
brings back
rpe65 converst from trans to cis
after that juts sort of goes back into photoreceptor and rhodopsinnnn
sin
i am isn
alyyy
rods more sensitive but photobleach really easily
dark adaptation is used to bright --> dark: dark current is open and decreasing dark current to adjust
light adap used to dar k--> light: ^^^ dark currrent
too dark --> ca because dark current open;;; want to decrease ca coming in so want to vvv dark curr;
ca has 3 targets: prevents cgmp binding; breaks down cgmp by inhibiting rhodopsin kinase which inhibits transducin which activates pde which breaks down cgmp; prevents synth of cgmp by gc
[prof] might ask to produce curve on slide 24 lol this is useless to you
abc brings to [20:00]
p ganglion have 1:1 convergence?? [31];go to ventral stream; 70% ; parvocellular (small)er
m ganglion are from rods/ocnes::::::: differnce between something is here is it moving; don't need a ton of acuity; so on dorsal side i guess idk; 10%; magnocellluar
k ganglion are literlaly just blue ahahhaahh even the fuckign review ta wa slike this doesn't fuckign matter fuckign loser
sup collic == blindsight
occipital cortex == can't perceive objects visually
meyer's loop goes laterally == upper side
dorsal radiations == lower side
[35] if lesion oen part of shstem: what kidn of effect
i'm good at nodding my head
have 2pee
am i really going to publish thsi
wlel i did just write fire so i guess it will be really easy; otherwise i wouon't be able to do it drunk but rn i think if i just ype "fire index.gmi" into the cli it will go wild
modality is juts type: smell taste touch vision etc
this is working well like idk how much i'll remember in the mornign but i'm advocating for myself like "you don't think we'll need to know x or y" type shit
if something hurts it won't go away, but when you put your shirt on you feel yourself put it on but then the feel of it being there just goes away afterward , ya kjnowwwww
noxious more slowly adapting
squaere is less adapting i think
firing frequency / time is the graph wher that holds
28:45 where are the types of taste buds?????
cn
fungiform 7
foliate 7/9
circumvallate 9
epiglottis 10
type 1 pretty glial: get rid of excess nt etc etc
type 2: sweet umami bitter dep on whcih type of receptors they have
type 3 sour but we didn't really deal with it
umami = t1r1/3
sweet = t1r2/3
bitter = t2r*
"sour he'll get into next time"
in mice saltty is enac but we don't know in humans so fuck this whole-ass line oh but he asked about this on the last exam so salt = enac in rodents[!!!]!!!!!
enac lets sodium in so it can be detected
[22] he's going to ask literally this entire fuckign slide
fuck
ip3 releases calcium but pka prevents that
M E C H A N I S M O F T R A NS D U C T I O N I N T ! R AND T @ R
FUCK
NOT FUCKING IT
FIXING
normall in cell u have some level of camp --> pka --| ip3
but when uactivate this, gα --> pde --| camp so fuck camp fuck pka hell ya @ ip3 ya boy do ya thinggg ip3333
trpm5 is ca dependent and lets in na
which depols and activates even more na channels --> atp release by calhm1 and pannexins or gap junctions
next slide same thing """"but a little more confusing""""
atp --> p2x/p2y
adp --> p2y
type2/3 can crosstalk and they have autoreceptors
fuck details but hell ya @ that shit b/c we really don't know a lot of the details
knowledge: table w/ 4 columns for diff tiss types
know the content you fucker aa
review session over
ooiwajeifoawejf
ok so im pretty sure i didn't dox myself in this file so im just gonna full send it so i can read it whiel i'm intoing food goodbye for nowf