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oxidized LDL and linoleic acid develop into foam cells

Quote from BMJ OpenHeart Study on Omega-6 vegetable oils source:

Once linoleic acid becomes oxidized in LDL, aldehydes and ketones covalently bind apoB, creating LDL that is no longer recognized by the LDL receptors in the liver but is now recognized by scavenger receptors on macrophages leading to the classic foam cell formation and atherosclerosis.

When linoleic acid oxidizes LDL and combines with it, it’s no longer recognized as LDL and is recognized by scavenger receptors inside the arterial wall where it develops into foam cells.

Is this why LDL was thought to be bad? A failure to recognize that it is not an abundance of LDL that is a problem of leading to plaque, but actually an abundance of oxidized LDL.

And is this why omega 6 is thought to lower LDL? Because it moves it into the arterial walls where it becomes plaque and is no longer detectable in the serum (ie requires cells to be extracted for analysis in order to find it)?

BMJ: OpenHeart Study on Omega-6 vegetable oils

Carved from raw notes on the study.

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oxidized LDL and linoleic acid develop into foam cells

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