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2017-06-09 03:53:47
Permanently cutting the daily calories you consume may turn out to have a
profound effect on your future life, according to some tantalising scientific
studies.
By Alex Riley
1 June 2017
In a restaurant setting sometime in the not-too distant future, a man and a
woman are on their first date. After the initial nerves subside, all is going
well.
The man is 33, he says, has been single for most of those years, and, although
he doesn t mention it, knows he is looking to settle down and have a family.
The woman replies that she is 52, has been married, divorced, and has children
in their early 20s. He had no idea she looked his age, or younger.
This is a dream of Julie Mattison from the National Institute on Ageing (NIA)
in the United States. She envisions a time when chronological age ticks by with
every year, but biological age can be set to a different timer, where elderly
doesn t mean what it does now.
It sounds far-fetched, but our society has already made great strides towards
that goal, thanks to advances in medicine and improvements in healthy living.
In 2014, for instance, the United States Health Interview Survey reported that
16% of people aged between 50 and 64 were impaired every day with chronic
illness. Three decades earlier that number was 23%. In other words, as well as
benefiting from longer lifespans, we are also experiencing longer healthspans
and the latter is proving to be even more malleable. To paraphrase and update
a speech from John F Kennedy given at the first White House Conference on
Ageing in 1961, life can indeed be added to years, rather than just years added
to life.
Healthspan is proving to be even more malleable than lifespan
So, what do we need to do to enhance the length and quality of our lives even
more? Researchers worldwide are pursuing various ideas, but for Mattison and
colleagues, the answer is a simple change in diet. They believe that the key to
a better old age may be to reduce the amount of food on our plates, via an
approach called calorie restriction . This diet goes further than cutting back
on fatty foods from time-to-time; it s about making gradual and careful
reductions in portion size permanently. Since the early 1930s, a 30% reduction
in the amount of food consumed per day has been linked to longer, more active
lives in worms, flies, rats, mice, and monkeys. Across the animal kingdom, in
other words, calorie restriction has proven the best remedy for the ravages of
life. And it s possible that humans have just as much to gain.
The idea that what a person eats influences their health no doubt predates any
historical accounts that remain today. But, as is often the case for any
scientific discipline, the first detailed accounts come from Ancient Greece.
Hippocrates, one of the first physicians to claim diseases were natural and not
supernatural, observed that many ailments were associated with gluttony; obese
Greeks tended to die younger than slim Greeks, that was clear and written down
on papyrus.
Spreading from this epicentre of science, these ideas were adopted and adapted
over the centuries. And at the end of the 15th Century, Alvise Cornaro, an
infirm aristocrat from a small village near Venice in Italy, turned the
prevailing wisdom on its head, and on himself.
If indulgence was harmful, would dietary asceticism be helpful? To find out,
Cornaro, aged 40, ate only 350g (12oz) of food per day, roughly 1000 calories
according to recent estimates. He ate bread, panatela or broth, and eggs. For
meat he chose veal, goat, beef, partridge, thrush, and any poultry that was
available. He bought fish caught from the local rivers.
Restricted in amount but not variety, Cornaro claimed to have achieved perfect
health up until his death more than 40 years later. Although he changed his
birthdate as he aged, claiming that he had reached his 98th year, it is thought
that he was around 84 when he died still an impressive feat in the 16th
Century, a time when 50 or 60 years old was considered elderly. In 1591, his
grandson published his posthumous three-volume tome entitled Discourses on the
Sober Life, pushing dietary restriction into the mainstream, and redefining
ageing itself.
With an additional boost of health into the evening of life, the elderly, in
full possession of their mental capacities, would be able to put decades of
amassed knowledge to good use, Carnaro claimed. With his diet, beauty became
the aged, not the youthful.
Longevity trials
Cornaro was an interesting man but his findings are not to be taken as fact by
any branch of science. Even if he was true to his word and did not suffer ill
health for nearly half a century, which seems unlikely, he was a case study of
one not representative of humans as a whole.
But since a foundational study in 1935 in white rats, a dietary restriction of
between 30-50% has been shown to extend lifespan, delaying death from
age-related disorders and disease. Of course, what works for a rat or any other
laboratory organism might not work for a human.
Long-term trials, following humans from early adulthood to death, are a rarity.
I don t see a human study of longevity as something that would be a fundable
research programme, says Mattison. Even if you start humans at 40 or 50 years
old, you re still looking at potentially 40 or 50 more years [of study]. Plus,
she adds, ensuring that extraneous factors exercise, smoking, medical
treatments, mental wellbeing don t influence the trial s end results is near
impossible for our socially and culturally complex species.
That s why, in the late 1980s, two independent long-term trials one at NIA
and the other at the University of Wisconsin were set up to study calorie
restriction and ageing in Rhesus monkeys. Not only do we share 93% of our DNA
with these primates, we age in the same way too.
Slowly, after middle age (around 15 years in Rhesus monkeys) the back starts to
hunch, the skin and muscles start to sag, and, where it still grows, hair goes
from gingery brown to grey. The similarities go deeper. In these primates, the
occurrence of cancer, diabetes, and heart disease increases in frequency and
severity with age. They re an excellent model to study ageing, says Rozalyn
Anderson, a gerontologist from the University of Wisconsin.
Sherman is the oldest Rhesus monkey ever recorded, nearly 20 years older than
the average lifespan for his species in captivity
And they re easy to control. Fed with specially made biscuits, the diets of the
76 monkeys at the University of Wisconsin and the 121 at NIA are tailored to
their age, weight, and natural appetite. All monkeys receive the full
complement of nutrients and minerals that their bodies crave. It s just that
half of the monkeys, the calorie restricted (or CR) group, eat 30% less.
They are far from malnourished or starving. Take Sherman, a 43-year-old monkey
from NIA. Mattison says that since being placed on the CR diet in 1987, aged
16, Sherman hasn t shown any overt signs of hunger that are well characterised
in his species.
Sherman is the oldest Rhesus monkey ever recorded, nearly 20 years older than
the average lifespan for his species in captivity. As younger monkeys were
developing diseases and dying, he seemed to be immune to ageing. Even into his
30s he would have been considered an old monkey, but he didn t look or act like
one.
The same is true, to varying extents, for the rest of his experimental troop at
NIA. We have a lower incidence of diabetes, and lower incidence of cancer in
the CR groups, says Mattison. In 2009, the University of Wisconsin trial
published similarly spectacular results.
Not only did their CR monkeys look remarkably younger with more hair, less
sag, and brown instead of grey than monkeys that were fed a standard diet,
they were healthier on the inside too, free from pathology. Cancers, such as
the common intestinal adenocarcinoma, were reduced by over 50%. The risk of
heart disease was similarly halved. And while 11 of the ad libitum ( at one s
pleasure, in Latin) monkeys developed diabetes and five exhibited signs that
they were pre-diabetic, the blood glucose regulation seemed healthy in all CR
monkeys. For them, diabetes wasn t a thing.
Overall, only 13% of the monkeys in the CR group had died of age-related causes
in 20 years. In the ad libitum group, 37% had died, nearly three times as many.
In an update study from the University of Wisconsin in 2014, this percentage
remained stable.
The results show that ageing itself is a reasonable target for clinical
intervention and medical treatment Rozalyn Anderson
We have demonstrated that ageing can be manipulated in primates, says
Anderson. It kind of gets glossed over because it s obvious, but conceptually
that s hugely important; it means that ageing itself is a reasonable target for
clinical intervention and medical treatment.
If ageing can be delayed, in other words, all of the diseases associated with
it will follow suit. Going after each disease one at a time isn t going to
significantly extend lifespan for people because they ll die of something else,
says Anderson. If you cured all cancers, you wouldn t offset death due to
cardiovascular disease, or dementia, or diabetes-associated disorders. Whereas
if you go after ageing you can offset the lot in one go.
Eating less certainly seemed to help the monkeys, but calorie restriction is
much tougher for people out in the real world. For one, our access to regular,
high-calorie meals is now easier than ever; with companies like Deliveroo and
UberEats, there is no longer a need to walk to the restaurant anymore. And two,
gaining weight simply comes more naturally to some people.
There s a huge genetic component to all of this and its much harder work for
some people than it is for others to stay trim, says Anderson. We all know
someone who can eat an entire cake and nothing happens, they look the exact
same. And then someone else walks past a table with a cake on it and they have
to go up a pant size.
Ideally, the amount and types of food we eat should be tailored to who we are
our genetic predisposition to gaining weight, how we metabolise sugars, how we
store fat, and other physiological fluxes that are beyond the scope of
scientific instruction at the moment, and perhaps forever.
But a predisposition to obesity can be used as a guide to life choices rather
than an inevitability. I personally have a genetic history of obesity running
through my family, and I practice a flexible form of caloric restriction, says
Susan Roberts a dietary scientist at Tufts University in Boston. I keep my BMI
at 22, and [have calculated] that that requires eating 80% of what I would eat
if my BMI was at 30 like every other member of my family. Roberts stresses
that it isn t hard she follows her own weight management programme using a
tool called iDiet to help her eat less but avoid feeling hungry or deprived of
enjoyment. If this wasn t possible, she adds, she wouldn t practise calorie
restriction.
Not only has Roberts seen the problems of obesity first-hand in her family, she
knows the benefits of CR better than most. For over 10 years she has been a
leading scientist in the Comprehensive Assessment of Long-Term Effects of
Reducing Intake of Energy trial, also known as Calerie. Over two years, 218
healthy men and women aged between 21 and 50 years were split into two groups.
In one, people were allowed to eat as they normally would (ad libitum), while
the other ate 25% less (CR). Both had health checks every six months.
Unlike in the Rhesus monkey trials, tests over two years can t determine
whether CR reduces or delays age-related diseases. There simply isn t enough
time for their development. But the Calerie trials tested for the next best
thing: the early biological signs of heart disease, cancer, and diabetes.
Published in 2015, the results after two years were very positive. In the blood
of calorie-restricted people, the ratio of good cholesterol to bad
cholesterol had increased, molecules associated with tumour formation called
tumour necrosis factors (TNFs) were reduced by around 25%, and levels of
insulin resistance, a sure sign of diabetes, fell by nearly 40% compared to
people who ate their normal diets. Overall, the blood s pressure was lower.
Significant health benefits may be garnered in an already healthy body, but
further trials are needed
Admittedly, some benefits may come from weight-loss. Earlier trials from
Calerie had included people that were obese as well as those with a healthy
body mass index (BMI) of 25 or below, and slimming down would have certainly
improved the welfare of the heavier participants. One thing that s been very
clear for a long time is that being overweight or obese is bad for you, says
Roberts. Diseases and disorders previously thought to be age-associated
diseases are now popping up in the obese population, she adds.
But the latest results suggested that significant health benefits can be
garnered in an already healthy body a person who isn t underweight or obese.
That is, someone whose BMI lies between 18.5 and 25.
Despite these results, evidence from further trials will be needed before
someone with an already healthy BMI should be advised to reduce their calorie
intake. (And anyone wanting to change their diet would be advised to consult a
medical professional beforehand.)
In the meantime, the scientists will be hoping that their rhesus macaques may
help us to understand exactly why calories restriction may have these effects.
With nearly 30 years of data on lives and deaths, and blood and tissue samples,
from nearly 200 monkeys, the work at NIA and the University of Wisconsin aim to
shine a light into the black box of calorie restriction, illuminating just how
it delays ageing.
With less food, is the metabolism forced to be more efficient with what it has?
Is there a common molecular switch regulating ageing that is turned on (or off)
with fewer calories? Or is there an as of yet unknown mechanism underpinning
our lives and deaths? The importance of monkeys like Sherman far outspans their
lives.
Calorie restriction may be one of the most promising avenues for improving
health and how long it lasts in our lives
Answers to such questions might be long in coming. If I cloned 10 of myself
and we all worked furiously, I don t think we d have it solved, says Anderson.
The biology is inordinately complicated. It s a worthwhile undertaking
understand how CR works and other treatments could then be used to target that
specific part of our biology. Ageing could be treated directly, that is,
without the need of calorie restriction. And I think that s really the golden
ticket, says Anderson.
Although lacking a neat explanation, calorie restriction is one of the most
promising avenues for improving health and how long it lasts in our lives.
There was nothing in what we saw that made us think caloric restriction doesn t
work in people, says Roberts, from the Calerie trial. And, unlike drug-based
treatments, it doesn t come with a long list of possible side effects. Our
people were not hungrier, their mood was fine, their sexual function was fine.
We looked pretty hard for bad things and didn t find them, says Roberts.
One expected issue was a slight decrease in bone density that is often tied to
gradual weight loss, says Roberts. But as a precaution, volunteers were
provided with small calcium supplements throughout the trial.
Even with such promising findings, this [the Calerie trial] is the first study
of its kind, and I don t think that any of us would feel confident in saying,
okay, we re going to recommend this to everyone in the world, says Roberts.
But it s a really exciting prospect. I think that delaying the progression of
chronic diseases is something that everyone can get behind and get excited
about, because nobody wants to live life with one of those.