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2007-10-25 10:28:53
By Maggie Fox, Health and Science Editor Wed Oct 24, 5:54 PM ET
WASHINGTON (Reuters) - A few nights without sleep can not only make people
tired and emotional, but may actually put the brain into a primitive "fight or
flight" state, researchers said on Wednesday.
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Brain images of otherwise healthy men and women showed two full days without
sleep seemed to rewire their brains, re-directing activity from the calming and
rational prefrontal cortex to the "fear center" -- the amygdala.
"It's almost as though, without sleep, the brain had reverted back to more
primitive patterns of activity, in that it was unable to put emotional
experiences into context and produce controlled, appropriate responses," said
Matthew Walker of the University of California Berkeley, who led the study.
That a lack of sleep can make people grumpy is hardly news. "We all know
implicitly the link between bad sleep the night before and bad mood the next
day. We are just adding the brain basis to what we knew," Walker said in a
telephone interview.
Walker and colleagues at Harvard Medical School used functional magnetic
resonance imaging, which can scan brain activity in real time, to see what was
going on in the brains of their 26 young adult volunteers.
Half were kept awake for a day, a night and another full day. The other half
slept as normal.
Writing in the journal Current Biology, Walker's team said they noticed
profound changes in the brain activity of those volunteers who stayed up.
"We found a strong overreaction from the emotional centers of the brain,"
Walker said. "It was almost as if the brain had been rewired, and connected to
the fright, flight or fight area in the brain stem."
SWINGING LIKE A PENDULUM
And lab workers noticed a difference in the behavior of the sleep-deprived
volunteers.
"They seemed to swing like a pendulum between the broad spectrum of emotions,"
Walker said. "They would go from being remarkably upset at one time to where
they found the same thing funny. They were almost giddy -- punch drunk."
Next Walker wants to test people who are chronically sleep-deprived, perhaps by
letting them have just 5 hours of sleep over several days. The average adult
needs 7 to 9 hours of sleep a night.
He said the findings may shed light on psychiatric diseases. "This is the first
set of experiments that demonstrate that even healthy people's brains mimic
certain pathological psychiatric patterns when deprived of sleep."
"Before, it was difficult to separate out the effect of sleep versus the
disease itself. Now we're closer to being able to look into whether the person
has a psychiatric disease or a sleep disorder."
A second study in the same journal suggests daylight-savings time regimes may
cause similar effects.
Till Roenneberg of Ludwig-Maximilian University in Munich, Germany examined the
sleep patterns of 55,000 people in Central Europe.
He found people's internal circadian clocks adjusted well when the clock moved
back in the autumn months, but failed to adjust when it moved forward, costing
them an hour of sleep, in the spring.
He said the effects held for weeks, perhaps causing people to feel continually
sleep-deprived in the spring and summer.