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More muscle power means lower Alzheimer's risk

2009-11-10 08:34:06

Mon Nov 9, 5:20 pm ET

NEW YORK (Reuters Health) Older people with stronger muscles are at reduced

risk of developing Alzheimer's disease compared to their weaker peers, a new

study shows.

Dr. Patricia A. Boyle of Rush Alzheimer's Disease Center in Chicago and her

colleagues found that the greater a person's muscle strength, the lower their

likelihood of being diagnosed with Alzheimer's over a four-year period. The

same was true for the loss of mental function that often precedes full-blown

Alzheimer's.

Studies have linked grip strength to Alzheimer's, while a person's weight and

level of physical activity also influence risk of the disease. To date,

however, no one has studied whether muscle strength in and of itself might play

a role in dementia risk, Boyle and her team note in November's Annals of

Neurology.

"These findings support the link between physical health and cognition in aging

and the importance of maintaining good physical function and strength," Boyle

told Reuters Health via E-mail.

The researchers measured the strength of nine muscle groups in the arms and

legs of 970 dementia-free men and women 54 to 100 years old (their average age

was around 80). They also tested the strength of study participants' breathing

muscles.

During follow-up, which lasted about four years, 138 people developed

Alzheimer's. These individuals were older and had worse mental function than

the rest of the study participants. They also were weaker.

But even after the researchers adjusted for age and education level-which can

influence Alzheimer's risk-they found that muscle strength had a strong

influence on the risk of the disease. People who ranked in the top 10 percent

for muscle strength were 61 percent less likely to develop Alzheimer's than the

weakest 10 percent. Stronger people also showed a slower decline in their

mental abilities over time.

The relationship between muscle strength and mild mental difficulties, which

occurred in an additional 275 people, was similar, with the strongest 10

percent being at 48 percent lower risk than the weakest 10 percent.

When the researchers looked at different types of muscle strength separately,

they found that grip strength and breathing-muscle strength had an independent

effect on Alzheimer's risk, but arm and leg strength didn't.

The most likely explanation for the mental function-muscle strength link is

that there is something going in the body that causes both muscle weakness and

loss of mental ability, Boyle said.

While the study couldn't show whether keeping one's muscles strong will keep

Alzheimer's at bay, staying fit is a good idea-and good for the brain-no matter

what, according to Boyle.

"We certainly think that it is important to be physically active and to work to

keep our muscles strong," she said. "Good physical health is important for good

brain function."

SOURCE: Archives of Neurology, November 2009.