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From Legal Highs by The Twentieth Century Alchemist, published sometime in the
early 1970's:
DANGEROUS COMBINATIONS
Unless one is very experienced in pharmacology, it is unwise to
experiment with combinations of drugs. Even when using a single drug, thought
should be given to all substances, both food and drug, which have been taken
recently. Most primitive people fast or at least abstain from certain
substances for several days prior to taking a sacrament. Substances most
universally avoides are alcohol, coffee, meat, fat and salt. Some drugs
potentiate others. For example, atropine will increase the potency of
mescaline, harmine, cannabis and the opiates. Many of the substances
discussed in this book are MAO inhibitors. MAO (monoamine oxidase) is and
enzyme produced in the body which breaks down certain amines and renders them
harmless and ineffective. An MAO inhibitor interferes with the protective
enzyme and leaves the body vulnerable to these amines. A common substance
such as tyramine, which is usually metabolized with little or no
pharmacological effect, may become dangerous in the presence of an MAO
innhibitor and cause headache, stiff neck, cardiovascular difficulties, and
even death. MAO inhibitors may intensify and prolong the effects of other
drugs (CNS depressants, narcotic analgesics, anticholinergics, dibenzazepine
antidepressants, etc.) by interfering with their metabolism. In the presence
of an MAO inhibitor many substances which are ordinarily non-active because of
their swift metabolism may become potent psychoactive drugs. This phenomenon
may creat a new series of mind alterants. However, because of the complex and
precarious variables involved, it is risky and foolish for anyone to
experiment with these possibilities on the non-professional level.
The most commonly used MAO inhibitors include hydrazines such as
iproniazid, Marsilid, Marplan, Niamid, Nardil, Catron; also non-hydrazines
such as propargylamines, cyclopropylamines, aminopyrazine derivatives,
indolealkylamines, and carbolines. MAO inhibiting materials discussed in this
book include yohimbine, various tryptamines, especially 5-MeO-DMT and the
alpha-methyltryptamines, and the various harmala alkaloids. The latter are
especially potent inhibitors, but, like yohimbine and the tryptamines, are
short-lasting in action (30 minutes to several hours). Some of the commercial
MAO inhibitors listed above are effective for several days to several weeks.
Among the material which may be dangerous in combination with MAO
inhibitors are sedatives, tranquilizers, antihistamines, narcotics and
alcohol--any of which can cause hypotensive crises (severe blood pressure
drop); and amphetamines (even diet pills), mascaline, asarone, nutmeg (active
doses), macromerine, ephedrine, oils of dill, parsley or wild fennel, beer,
wine, cocoa, aged cheeses and other tyrosine-containing foods (tyrosine is
converted to tyramine by bacteria in the bowel)--any of which can cause
hypertensive crises (severe blood pressure rise).
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