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2009-03-03 08:09:27
NEW YORK (Reuters Health) People with hay fever -- more accurately termed
allergic rhinitis -- may find themselves with a migraine after they use a nasal
steroid spray to relieve their stuffy noses.
Dr. Jitka Pokladnikova, of Charles University in Prague, and colleagues
reviewed the World Health Organization's global database and other sources and
found an unexpected cluster of 38 cases of migraine suspected to be related to
the use of intranasal corticosteroids.
The suspected intranasal corticosteroids included six different drugs:
fluticasone, beclomethasone, budesonide, mometasone, flunisolide, and
triamcinolone. In 24 cases the intranasal corticosteroid was the only drug
used, the researchers report in the medical journal Cephalalgia.
Re-exposure to the intranasal corticosteroid led to a relapse of migraine in
eight patients. None of the drugs exceeded the maximum daily recommended dose
range in any reported case.
In the 16 reports where time to onset was recorded, migraine developed early in
the course of intranasal corticosteroid treatment in 12 cases -- within the
first four days.
A connection between allergic rhinitis and migraine has already been
established. The new findings suggest that, "in addition, intranasal
corticosteroids might cause or worsen migraine or migraine-like headache,"
Pokladnikova and colleagues conclude.
SOURCE: Cephalalgia, March 2009.