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If used in numbers, atomic bombs not only can nullify any nation's military effort, but can demolish its social and economic structure and prevent their re-establishment for long periods of time. With such weapons, especially if employed in conjunction with other weapons of mass destruction such as pathogenic bacteria, it is quite possible to depopulate vast areas of the earth's surface, leaving only vestigal remnants of man's material works. Report of the Joint Chiefs of Staff, Operations Crossroads, June 30, 1947.