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2008-02-26 06:05:31
Anti-depressant prescription rates have soared
Study author
New generation anti-depressants have little clinical benefit for most patients,
research suggests.
A University of Hull team concluded the drugs actively help only a small group
of the most severely depressed.
Marjorie Wallace, head of the mental health charity Sane, said that if these
results were confirmed they could be "very disturbing".
But the makers of Prozac and Seroxat, two of the commonest anti-depressants,
said they disagreed with the findings.
A spokesman for GlaxoSmithKline, which makes Seroxat, said the study only
looked at a "small subset of the total data available".
Reviewed data
And Eli Lilly, which makes Prozac, said that "extensive scientific and medical
experience has demonstrated it is an effective anti-depressant".
There seems little reason to prescribe anti-depressant medication to any but
the most severely depressed patients
Professor Irving Kirsch
University of Hull
Patients are advised not to stop taking their medication without first
consulting a doctor.
The researchers accept many people believe the drugs do work for them, but
argue that could be a placebo effect - people feel better simply because they
are taking a medication which they think will help them.
In total, the Hull team, who published their findings in the journal PLoS
Medicine, reviewed data on 47 clinical trials.
They reviewed published clinical trial data, and unpublished data secured under
Freedom of Information legislation.
They focused on drugs which work by increasing levels of the mood controlling
chemical serotonin in the brain.
These included fluoxetine (Prozac) and paroxetine (Seroxat), from the class
known as Selective Serotonin Reuptake Inhibitors (SSRIs), alongside another
similar drug called venlafaxine (Efexor) - all commonly prescribed in the UK.
The number of prescriptions for anti-depressants hit a record high of more than
31 million in England in 2006 - even though official guidance stresses they
should not be a first line treatment for mild depression.
There were 16.2m prescriptions for SSRIs alone.
The researchers found that even the positive effects seen on severely depressed
patients were relatively small, and open to interpretation.
HAVE YOUR SAY The best way is to leave the pills alone, get a grip and face up
to problems Iain Connochie, Doncaster
The seemingly good result was based more on the fact that the dummy placebo
pills produced less of an effect in these patients, rather than on any notable
positive response to the anti-depressants themselves.
Lead researcher Professor Irving Kirsch said: "The difference in improvement
between patients taking placebos and patients taking anti-depressants is not
very great.
"This means that depressed people can improve without chemical treatments.
"Given these results, there seems little reason to prescribe anti-depressant
medication to any but the most severely depressed patients, unless alternative
treatments have failed to provide a benefit."
Professor Kirsch said the findings called into question the current system of
reporting drug trials.
Revieweing guidance
Dr Tim Kendall, deputy director of the Royal College of Psychiatrists Research
Unit, has published research concluding that drug companies tend only to
publish research which shows their products in a good light.
These medicines have been licensed by a number of regulatory authorities around
the world, who looking at all the evidence, have determined that they do work
better than placebo
Dr Richard Tiner
Association of the British Pharmaceutical Industry
He said the Hull findings undermined confidence in the ability to draw
meaningful conclusions about the merit of drugs based on published data alone.
He called for drug companies to be forced to publish all their data.
The National Institute for Health and Clinical Excellence (NICE) is currently
reviewing its guidance on the use of antidepressants.
Marjorie Wallace of Sane commented: "If these results were upheld in further
studies, they would be very disturbing.
"The newer anti-depressants were the great hope for the future.... These
findings could remove what has been seen as a vital choice for thousands in
treating what can be a life-threatening condition."
Dr Richard Tiner, of the Association of the British Pharmaceutical Industry,
said there was no doubt that was a "considerable placebo effect" from
anti-depressants when treating people with mild to moderate symptoms.
But he said no medicine would get a licence without demonstrating it was better
than a placebo.
Dr Tiner said: "These medicines have been licensed by a number of regulatory
authorities around the world, who looking at all the evidence, have determined
that they do work better than placebo."
Alan Johnson, the Health Secretary, has announced that 3,600 therapists are to
be trained during the next three years in England to increase patient access to
talking therapies, which ministers see as a better alternative to drugs.