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By Michelle Roberts
Health reporter, BBC News
Centenarians with the bodies of 50-year-olds will one day be a realistic
possibility, say scientists.
Half of babies now born in the UK will reach 100, thanks to higher living
standards, but our bodies are wearing out at the same rate.
To achieve "50 active years after 50", experts at Leeds University are spending
50m over five years looking at innovative solutions.
They plan to provide pensioners with own-grown tissues and durable implants.
New hips, knees and heart valves are the starting points, but eventually they
envisage most of the body parts that flounder with age could be upgraded.
New lease of life
The university's Institute of Medical and Biological Engineering has already
made a hip transplant that should last for life, rather than the 20 years
maximum expected from current artificial hips.
The combination of a durable cobalt-chrome metal alloy socket and a ceramic
ball or "head" means the joint should easily withstand the 100 million steps
that a 50-year-old can be expected to take by their 100th birthday, says
investigator Professor John Fisher.
Meanwhile, colleague Professor Eileen Ingham and her team have developed a
unique way to allow the body to enhance itself.
To replace all donor tissue using this technology will take 30 to 50 years
Material scientist Professor Christina Doyle
The concept is to make transplantable tissues, and eventually organs, that the
body can make its own, getting round the problem of rejection.
So far they have managed to make fully functioning heart valves using the
technique.
It involves taking a healthy donor heart valve - from a human or a suitable
animal, such as a pig - and gently stripping away its cells using a cocktail of
enzymes and detergents.
The inert scaffold left can be transplanted into the patient without any fear
of rejection - the main reason why normal transplants wear out and fail.
Proof of concept
Once the scaffold has been transplanted, the body takes over and repopulates it
with cells.
Trials in animals and on 40 patients in Brazil have shown promising results,
says Prof Ingham.
They have licensed the technology to the NHS National Blood and Transplant
Tissue Services so it can be used on any UK donated human tissue in the future.
The NHS is already looking into using the method on donor skin for burns
patients.
Professor Christina Doyle of Xeno Medical, the medical device company that is
developing the technologies, said the holy grail was to remove the heavy
reliance on donor organs.
"That's where the technology will lead us eventually."
But she said: "To replace all donor tissue using this technology will take 30
to 50 years. Each single product will need to be designed and tested
individually."
Prof Doyle said experts elsewhere were also working on similar regenerative
therapies, but grown entirely outside of the body, to ensure that people can
continue being as active during their second half-century as they were in their
first.