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From: mmanzo@mail.sas.upenn.edu (Marco Manzo) Newsgroups: alt.drugs Subject: FAQ list-Opioid Analgesics Date: 29 May 1994 19:16:02 GMT Message-ID: <2sapli$nca@netnews.upenn.edu> As suggested in the "Hydromorphone, Oxymorphone" thread, here is a sort of FAQ-list/summary of the opioid pain killers available in the United States. CATEGORY I. STRONG AGONISTS-- SEVERE PAIN ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ generic name trade name recommended duration Controlled dosage of action substance category HYDROMORPHONE DILAUDID 2-4 mg. every 4-5 hours Schedule II 4-6 hours. narcotic dosages avail: 1,2,3,4,10 mg.tabs Parenteral (injection) 1,2,3,4 mg./mL ampules LEVORPHANOL LEVO-DROMORAN 2-3 mg. every 4-5 hours Schedule II 6-8 hours narcotic dosages: 2 mg. tabs; injection: 2 mg./mL MEPERIDINE DEMEROL 50-150 mg. 2-4 hours Schedule II every 3-4 hours narcotic dosages: 50,100 mg. tabs; injection: 25,50,75,100 mg. vials METHADONE DOLOPHINE 40 mg. every 4-6 hours Schedule II dosages: 5,10,40 mg. tabs; 24 hours; Narcotic injection: 10 mg./mL 2.5-10 mg.injection the oral form is used every 3-4 hours only in detoxification programs MORPHINE SULFATE varies: 10-30 mg. 4-5 hours Schedule II dosages: 10,15,30 mg. tabs; every 4 hours; Narcotic injection: 2,4,5,8,10,15 mg/mL 30 mg. controlled release tablets every 8-12 hours OXYMORPHONE NUMORPHON 5 mg. supppository 3-4 hours Schedule II dosages: 5 mg. suppos. every 4-6 hours; Narcotic 1, 1.5 mg/mL injection 1-1.5 mg. injection every 4-6 hours. STRONG AGONISTS FOR INJECTION ONLY: FENTANYL SUBLIMAZE 0.05-0.1 mg. 1-1.5 hours Schedule II dosages: 0.05 mg./mL for repeat in 2 hours Narcotic injection if necessary SUFENTANIL SUFENTA 1-30 micrograms/kg. Schedule II dosages: 50 micrograms injected as needed for Narcotic per mL in 1,2,5 mL ampules anesthesia ALFENTANIL ALFENTA 0.5-3 micrograms/kg./minute Schedule II dosages: 500 micrograms/mL IV infusion in balanced anesthesia ampules for injection CATEGORY II -- MILD TO MODERATE AGONISTS - MODERATE TO SEVERE PAIN ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ GENERIC NAME TRADE NAME RECOMMENDED DURATION OF CONTROLLED DOSAGE ACTION SUBSTANCE CATEGORY CODEINE SULFATE OR PHOSPHATE 15-60 mg. every 3-4 hours Schedule II dosages: 15,30,60 mg. tablets; 4-6 hours (when combined with 30,60 mg./mL for injection acetominophen or asprin it is a Schedule III Narcotic) OXYCODONE PERCODAN (with asprin) PERCOCET (with tylenol) dosages: 5 mg. oxycodone per tablet 5 mg. every 3-4 hours Schedule II 6 hours Narcotic HYDROCODONE VICODIN,LORTAB 5-7 mg. every 3-4 hours Schedule III BITARTRATE LORCET, HYDROCET 4-6 hours Narcotic dosages: either 2.5, 5, or 7 mg. hydrocodone with either asprin or tylenol CATEGORY III -- WEAK AGONISTS -- MILD TO MODERATE PAIN ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ GENERIC NAME TRADE NAME RECOMM. DOSAGE DURATION OF CONTROLLED ACTION SUBSTANCE CATEGORY PROPOXYPHENE DARVON 50-100 mg. every 4-5 hours Schedule IV PROPOXYPHENE 4 hours Narcotic NAPSYLATE DARVOCET N-50 DARVOCET N-100 CATEGORY IV -- MIXED AGONISTS/ANTAGONISTS -- MODERATE TO SEVERE PAIN ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ GENERIC NAME TRADE NAME RECOMM. DOSAGAE DURATION OF CONTROLLED ACTION SUBSTANCE CATEGORY PENTAZOCINE TALWIN-NX 50-100 mg. 3 hours Schedule IV dosages: 50 mg. tablets; every 3-4 hours; Narcotic 30 mg./mL in 1 and 2 mL 30 mg. injection (Pentazocine is mixed ampules for injection every 3-4 hours with Naxolone [an opiate antagonist] to prevent crushing of tabs. for intravenous injection) OTHER MIXED AGONIST-ANTAGONISTS: BUPRENORPHINE BUPRENEX Schedule V dosage: 0.3 mg./mL ampules for injection. BUTORPHANOL STADOL dosage: 1 and 2 mg./mL vials and syringes for injection Not a controlled substance because of the strong antagonist efficacy NALBUPHINE NUBAIN dosage: 10 and 20 mg./mL vials and syringes for injection Not a controlled substance because of the strong antagonist efficacy