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My note on Ketamine raised some response from the net, and I
thought I would respond to mind-l in general, as well as to the
specific folks who were curious.  


	
IMPORTANT DISCLAIMER*  I am a scientific PhD, not a physician


                        Neither I nor my employer take any
                        responsibility for its accuracy or
                        possible use.

First, ketamine is in current use as both a veternary and a
human anesthetic.  It is called "dissociative" in action, which
means that the mind is "separated" from the body.  In many
cases, this separation results in profound hallucinations and
the sensation of entering another reality.  In human use, a
benzodiazapine like Versed is generally used along with
ketamine to induce amnesia concerning the "emergence
reactions".

The most easily obtained reference about ketamine is
the Physicians Desk Reference.  Under the heading "Ketalar",
this gives a great deal of information about the drug.  Of
course, since this is a general medical reference, much of the
info of interest to mind-l is not present, but it should be
read anyway.  

Perhaps the most important property of ketamine is that,
despite the induction of both anesthesia and dissociation, the
cough and gag reflexes *USUALLY* are not affected.  This means
that, contrary to most other agents which will produce
anesthesia and/or unconsciousness, it is very unlikely that a
person using ketamine will aspirate their own saliva and other
excretions.  This is *NOT* guarenteed, but is a pretty good
bet.  Solo use, however, remains dangerous.

Ketamine is generally available for non-medical uses as
ketamine hydrochloride.  Some major chemical houses carry it at
a cost of about $10/gm.  I don't know if there are other
sources which are cheaper, or if the veterinary form is easily
available.  

Dosages are discussed in the PDR, but are generally in the
range of 100-500 mg.  Conventional useage is intravenous or
intramuscular, but "recreational" use is apparently more often
through insufflation (snorting) or solution ingestion.  These
latter approaches are probably only effective with the
hydrochloride form, but the reported doses are similar to the
conventional medical doses.  


As in all such experiments, if you must do this, be sure of
your materials and start slow, with small doses separated by
enough time to really come back to Earth between experiments.

Mahalo