Created: 2020-11-14T06:23:10-06:00
This card pertains to a resource available on the internet.
In this study, a chlorine dioxide solution (UC-1) composed of chlorine dioxide was produced using an electrolytic method and subsequently purified using a membrane.
UC-1 was determined to contain 2000 ppm of gaseous chlorine dioxide in water.
The efficacy and safety of UC-1 were evaluated.
The antimicrobial activity was more than 98.2% reduction when UC-1 concentrations were 5 and 20 ppm for bacteria and fungi, respectively.
The half maximal inhibitory concentrations (IC50) of H1N1, influenza virus B/TW/71718/04, and EV71 were 84.65 ± 0.64, 95.91 ± 11.61, and 46.39 ± 1.97 ppm, respectively.
A 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test revealed that the cell viability of mouse lung fibroblast L929 cells was 93.7% at a 200 ppm UC-1 concentration that is over that anticipated in routine use.
Moreover, 50 ppm UC-1 showed no significant symptoms in a rabbit ocular irritation test.
In an inhalation toxicity test, treatment with 20 ppm UC-1 for 24 h showed no abnormality and no mortality in clinical symptoms and normal functioning of the lung and other organs.
A ClO₂ concentration of up to 40 ppm in drinking water did not show any toxicity in a subchronic oral toxicity test.
Herein, UC-1 showed favorable disinfection activity and a higher safety profile tendency than in previous reports.