From: pck@acsu.buffalo.edu (Philip C. Kilinskas) Newsgroups: alt.psychoactives Subject: Re: Ecstasy!! Message-ID: Date: 16 Jan 93 05:43:31 GMT Organization: UB Lines: 1730 This, and other interesting psychoactives material, are available via anonymous ftp from ftp.u.washington.edu. Not yet organized, but maybe of interest to some.... contains Shulgin's bibliography too. ****************************** XTC FAQ Unorganized version 0.0 19 Jun 91 From: honig@calliope.ICS.UCI.EDU ("David A. Honig") Subject: Compleat Info on X XTC MDMA MDA etc. Last Update: 19 Jun 91 23:38:30 GMT .............................. MDMA ;(extacy) (XTC); metheylenedimethoxymethamphetamine. Is an analog of MDA (methylenedimethoxyamphetamine). MDA Was first synthesized in 1917 by Parke-Davis company as an appetite suppressant drug. The drug, in addition to suppressing appetite, produced what is now termed as an "entacto-effect" in the test subjects. Because of the adverse side effects, Parke-Davis did not market the drug and let the patent expire. The drug resurfaced in the 1960's along with the advent of many other psychoactive substance. Known negative side effects are around a 40% reduction of serotonergic synapses in the rat brain with a 5mg/kg dosage (no data is available for neurotoxicity in humans). Cerebral spinal fluid of admitted users has been shown to have a marked decrease in 5-HT levels. More on the pharmacology later.... .............................. I can't find the strand, but this is intended to correct/clarify some recent discussions of DOM (AKA STP). When DOM (2,5-dimethoxy-4-methylphenylisopropylamine) first hit the streets of San Francisco in the late sixties, it was distributed in tablets of 10 or 20 mg. Threshold effects begin at 1 mg (you get muscle tremors, facial flushing, and minor sensory amplification) and the more you do, the longer and more intense the trip. Obviously, if people took two or three tablets, they'd be in for a long trip. So, the stories of DOM trips lasting for days are just the result of people not knowing the ED. It is really a nice psychedlic at 5 mgs or so, no worse than LSD. As for the stories of antipsychotics not helping or worsening a DOM trip, such stories are nonsense from a pharmacological standpoint. There is nothing really unusual about DOM as a psychedelic, if anything it is a cleaner 5-HT2 agonist than LSD. This rumor was studied using 50-200 m g chlorpromazine to counteract large DOM doses. While the effects of DOM w eren't completely reversed, the chlorpromazine did calm the people down. Check out Snyder et al (1968) in Amer. J. Psychiat. 125: 357-364 and Hollister et al (1969) in Psychopharmacologia 14: 62-73 for studies on humans with low and high doses respectively. .............................. Subject: Re: Aminization of Nutmeg or Calamus mcbeeb@jacobs.CS.ORST.EDU (Brian Mcbee) writes: >So, if I had a batch of nutmeg or calamus, and I soaked it in an aqueous >solution of ammonia... Hmm. Anyone have a recipe for making quick and >dirty psychedelics from natural precursors? Something that doesn't involve >expensive lab equipment or dangerous chemicals? Try refluxing an Et2O extract of either in NH2CH3 with 200 mesh Al and HgCl2 for a few hours. Try this and you will see God in short order. Quick and dirty aminations are hard enough to do in your bath tub with pure reagents. .............................. alt.drugs by the one and only Tyrone Slothrop. Please edit Asarone can be easily extracted from Acorus calamus roots by steam distillation. This is a really nice process because it doesn't require the use of any smelly, flammable and poisonous solvents. I've used it to extract safrole from sasafrass roots. This will get rid of most of the ``gunk'', but of course you will have a mix of aromatic oils. Shulgin (1978) states: ``It is used as a medicine by the indians of northern Canada (Hoffer and Osmond, 1967) where it is known by the name of rat-root, and is claimed to have intoxicating properties similar to those of LSD. The conversion of asarone to TMA-2 is easily realized...'' However, asarone is not the ``precursor to all the MDA analogs''. It is the precursor to TMA-2. This is discussed in chapter 5 of Strafford (1983). TMA-2 is 2,4,5-trimethoxyphenylisopropylamine. Shulgin (1976) describes the effects as follows: The first indications of intoxication usually noted are signs of physical disturbance such as nausea, paraesthesia, and a modest reflexive mydriasis. The central sensory changes appear in the second hour and are character- ized by some exaggeration of visual input (especially in the appreciation of colors and contrasts of lighting) and of empathy with irrational objects in one's environment. These preludes lead to a plateau, form three to about six hours following administration, which is an impressive altered state of consciousness virtually free of the distortions and portentousness so com- mon with LSD. The experience dissipates gradually, and is usually com- pleted in 8-10 hours. A sharp dose-response curve exists for TMA-2 in that several additional toxic symptoms have been reported at 25-30 mg levels. There can be a pervasive mausea throughout the entire experimental period, accompanied by actual vomiting, apparent fainting, and brief but repeated periods of amnesia. Peripheral vision can be lost (this, apparently, of hysterical origin) and the accompanying fear of being irrepaprably severed from reality has led to situations that have proved difficult to manage. Here was a world of simplicity and certainty no acidhead, no revolutionary anarchist would ever find, a world based on the one and zero of life and death. Minimal, beautiful. The patterns of lives and deaths.... ...it would all be done with keys on alphanumeric keyboards that stood for weightless, invisible chains of electronic presence or absence. If patterns of ones and zeros were ``like'' patterns of human lives and deaths, if everything about an individual could be represented in a computer record by a long string of ones and zeros, then what kind of creature would be represented by a long string of lives and deaths? It would have to be up one level at least -- an angel, a minor god, something in a UFO. It would take eight human lives and deaths just to form one character in this being's name -- its complete dossier might take up a considerable piece of the history of the world. We are digits in God's computer... And the only thing we're good for, to be dead or to be living, is the only thing He sees. What we cry, what we contend for, in our world of toil and blood, it all lies beneath the notice of the hacker we call God. -- Pynchon (1990) - Tyrone Slothrop - from his scattering Hoffer, A., and H. Osmond. 1967. The Hallucinogens, pp. 55-56. Academic Press, New York. Pynchon, Thomas. 1990. Vineland. Little, Brown and Co. Pp. 385. Shulgin, A. T. 1976. Profiles of psychedelic drugs. 2. TMA-2. J. Psychedelic Drugs 8: 169. _____. 1978. Psychotomimetic drugs: structure-activity relationships. In: Handbook of Psychopharmacology, Vol. 11: Stimulants. Iversen, Iversen and Snyder [eds.]. Plenum Press, New York. Pp. 243-333. Strafford, Peter. 1983. Psychedelics Encyclopedia. Houghton Mifflin. Pp. 420. -------end forwarded message-------- ----------------begin forwarded message------------------ Subject: Re: Legal and better highs >MDE - "Eve" An intellectual buzz, no emotional effects >2-CB - (CBR) MDMA analog, visuals(sometimes frightening) > Ultimate in telepathic communications > >2CT2 - Laboratory exotic - dark earthy visuals, like shrooms >DIPT - Obscure compound - said only to effect perception of music >DOET - "visual, pretty & pyschedlic, low dosages remove writing > blocks CBr a MDMA analog? CBr is 2,5-Dimethoxy-4-Bromophenethylamine. The "sometimes frightening" part probably comes from taking more than the full dose, and the literature suggests that with larger dosages come disproportionately larger responses, unlike some other psychedelics we all know and love. I've had very enlightening experiences with CBr, and they grew better in quantum leap fashion. + wonderful and gently insightful (semi-wilderness, daytime, friends). + profoundly sexual with glimpses of bird-animal forms (indoors, nightime, lover) minor telepathic imagery. + sexual and shamanic, native american imagery (indoors, day-night, alone). + profound native american imagery (indoors, night, after cannabis, friend) actually slept a bit (too much cannabis) and awoke to the most wonderful visuals (friend in other room - ditto). + full-blown spirit animals all night long (desert, night, friend, good THC 1/2 way thru trip) - mountain lion (very playful) and eagle most prominent two deer (incredibly loving), a wolf (very brief), fantastic living plant spirits, entities in mountain, mucho native american imagery, et. al. very telepathic with friend. brief teleportation/desert-zoom experience. understood the ancients' fascination with constellations. imparted with sudden knowledge in extreme detail - confirmed later by ex-lover, scared ex-lover shitless. My last experience with CBr changed my life in many profound ways (for the better). With THC and a little concentration I can get back to some of those places. With no THC and a lot of concentration I can get back to some of those places. Remember. I believe CBr is recognized as an enthogen and an entactogen, and unfortunately it's now Schedule 1. :-( Put this one on the top of the list of drugs to be legalized. DO NOT TAKE ANY DRUG YOU DO NOT UNDERSTAND. KNOW THE SOURCE. >A friend of mine needs some information on a chemical called _SAPHROL_... Safrole is 4-allyl-1,2-methylenedioxybenzene. Sassafras oil is about 75% safrole. It has quite a pleasant and characteristic odor. >The way he spoke about it makes me think that it is an illegal substance >used in making some illicit substance. The methylenedioxybenzene nucleus is found in MDA and MDMA. Amination at the appropriate carbon of the olefinic side chain yields the former, methylamination, the latter. I think this reaction is non-trivial due to conjugation of the double bond with the aromatic ring; the syntheses I have seen start with the ketone. In article eesnyder@boulder.Colorado.EDU (Eric E. Snyder) writes: [regarding safrole] >methylamination, the latter. I think this reaction is non-trivial due >to conjugation of the double bond with the aromatic ring; the syntheses ^^^^^^^^^^^ ^^ ^^^ ^^^^^^ ^^^^ >I have seen start with the ketone. That's isosafrole. The reaction isn't too difficult. One tries for an anti-Markownikov addition in the presence of peroxide or other source of free radicals. For the purposes mentioned, safrole undergoes the appropriate addition very conveniently. Both safrole and isosafrole do have a pleasant odor and have been used in flavorings, but perhaps they can't be used anymore due to a possible cancer risk? Although I think some "natural" root beers can contain some amount of "natural" safrole, but none can be added. Regulations, regulations... -- David J. Heisterberg djh@osc.edu We are NOT all The Ohio Supercomputer Center djh@ohstpy.bitnet Keynesians now. Columbus, Ohio 43212 ohstpy::djh >Just for the record, mescaline is 3,4,5-trimethoxyphenylethylamine. It does not >contain an indole ring, it is one of the hallucinogenic amphetamines, as is MDMA. ...just for the record, mescaline is *not* a so-called psychedelic amphetamine. Amphetamine, aka phenylisopropylamine, has an alpha methyl group, and thus possesses a chiral center. Phenylethylamines are achiral. This is important because the alpha methyl group makes phenylisopropylamines poor substrates for MAO. In contrast, phenylethylamines are excellent substrates for MAO. As a result, mescaline is not a potent psychedelic (ED ca. 300 mg). However, 3,4,5-TMA, the phenylisopropylamine analog of mescaline is active at around 20 mg. eesnyder@boulder.Colorado.EDU (Eric E. Snyder) writes: >...just for the record, mescaline is *not* a so-called psychedelic amphetamine. >Amphetamine, aka phenylisopropylamine, has an alpha methyl group, and thus >possesses a chiral center. Phenylethylamines are achiral. This is important >because the alpha methyl group makes phenylisopropylamines poor substrates for >MAO. In contrast, phenylethylamines are excellent substrates for MAO. As a >result, mescaline is not a potent psychedelic (ED ca. 300 mg). However, >3,4,5-TMA, the phenylisopropylamine analog of mescaline is active at around >20 mg. Yeah, but does it get you off? .............................. This is some information I recieved by email regarding a "new form" of methamphetamine which has been reportedly appearing in Hawaii.... Here are some passages from an article titled "A Chemical and Pharmacological Review of U4Euh/Intellex" by the "New Age Chemist" in volume 4 of Psychedelic Monographs & Essays (available from Rosetta, PO Pox 4611, Berkeley, CA 94704 ). "Chemical names: 4-methyl aminorex, 4-methyl-5-phenyl-2-amino-oxazoline, 4,5-dihydro-4-methyl-5-phenyl-oxazolamine. (note: oxazoline appears to be the ring formed by -O-C(NH2)=N-CH(CH3)-CH- 1 2 3 4 5 "Common names: U4Euh, Euphoria, Intellex, Ice, Verbosamine "History: 4-methyl aminorex was first synthesized and its anorexigenic and stimulant properties discovered by the research group of George Poos at McNeil labs in Ft. Washington, PA, in the early 60's. [see J. Med. Chem, 6:266, 1963]. ... Attention was primarily directed at the anorexegenic properties and the central effects were regarded as unwanted side effects. "When a high production lab was discovered in Gainesville, Florida in 1986, the DEA investigated and the material has subsequently been consigned to Schedule I under the emergency scheduling provision of the Controlled Substance Act for a one year period beginning Oct. 15, 1987. (i don't know what the final disposition of the drug was but it's not hard to guess...) "Chemistry: 4-methyl aminorex is prepared through an addition and spontaneous cyclizing reaction involving PPA. (another paper in the the same volume says it is synthesized from PPA and cyanogen bromide) The simplicity of the synthesis, the ready availability of precursors, high yields, and the interesting central effects suggest that this material will be around for a long time to come. "Pharmacological profile: ... Quantitatively, the experience is similar to a long-lasting MDMA intoxication superimposed with methamphetamine, with the added benefits of easy verbalization, free association, integration, and elaboration of previous insights, making it a useful tool for lecturers... Nothing is know about the pharmacokinetics or pharmacodynamics of 4-methyl aminorex. The central effects (sympathomimetic) are believed to be the result of increased release of catecholamines, and mimicking the effects of these transmitters at receptor sites in the brainstem. Subject: Ice, 4-methylaminorex (was Re: Mad About MDA...) Message-ID: <1854@ursa-major.SPDCC.COM> Date: 26 Feb 90 18:43:05 GMT References: <11478@nigel.udel.EDU> <1990Feb23.043735.3160@spectre.ccsf.caltech.edu> <357@tau-ceti.isc-br.com> Reply-To: dyer@ursa-major.spdcc.COM (Steve Dyer) Distribution: alt Organization: S.P. Dyer Computer Consulting, Cambridge MA Lines: 17 Aminorex was withdrawn from the European market in the late 60's after women who were given this drug as an appetite suppressant developed chronic pulmonary hypertension, leading in most cases to death and significant impairment in the rest. It was never marketed in the U.S. Since the mechanism of this deleterious effect is not known, and knowing how similar 4-methyl aminorex is chemically and pharmacologically to aminorex (it's related to aminorex in the same way as methamphetamine is related to amphetamine or phendimetrazine is to phenmetrazine), it seems imprudent to recommend its recreational use. .............................. In article <2160@sunset.MATH.UCLA.EDU> trainor