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This is a very interesting question. Firstly it is important to mention that not all antibiotics are fungally derived. However regarding you question, it is indeed likely that many mechanisms of antibiotic resistance existed long before the use of antibiotics in human and veterinary medicine. Inappropriate usage and overusage of antibiotics has prompted the natural selection of resistant organisms and increased acquisition of antibiotic resistant genes, making it a global health crisis. So it will be the case that some fungi will be susceptible to certain antibiotic resistant bacteria. At the same time, novel antibiotic resistant mechanisms have also evolved as a direct consequence of overusing antibiotics through chance by genetic mutation.
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