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created by [deleted] on 20/09/2021 at 20:12 UTC

1 upvotes, 1 top-level comments (showing 1)

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Comment by PlacatedPlatypus at 21/09/2021 at 13:32 UTC

7 upvotes, 1 direct replies

LncRNAs very rarely have open reading frames. They do have introns and are weakly spliced,[1] but ORFs pop up very rarely (Possibly a relic of evolving to overlap protein-coding genes).[2]

1: http://m.genome.cshlp.org/content/22/9/1616.short

2: https://www.nature.com/articles/srep42775

Most ORFs left in an lncRNA-coding region would activate nonsense-mediated decay quite quickly and are unlikely to be able to code for anything.

However, in rare cases they are able to actually code for functional micropeptides.