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View submission: Ask Anything Wednesday - Biology, Chemistry, Neuroscience, Medicine, Psychology
Photodynamic therapy isn't light only therapy, but also includes drugs that become active when activated by light. So the tissue penetration problem may be related to those drugs as well rather than only the light.
At the same time, those drugs turn toxic when exposed to light and even though generally photodynamic therapy is gentler than let's say systemic chemotherapy, it can still cause burns and tissue damage. If you put those drugs deeper into the tissue, all you get is further tissue damage affecting healthy tissue as well as malignant tissue.
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