https://academic.oup.com/braincomms/article/7/1/fcae448/7920652?login=false
created by poormrblue on 08/01/2025 at 22:29 UTC
81 upvotes, 5 top-level comments (showing 5)
Comment by AutoModerator at 08/01/2025 at 22:29 UTC
1 upvotes, 0 direct replies
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Comment by autisticpig at 09/01/2025 at 01:22 UTC
18 upvotes, 0 direct replies
'PVI’, defined as having a COVID-19 infection before any SARS-CoV-2 vaccination
‘BTI’, defined as an infection more than 2 weeks after receiving any SARS-CoV-2 vaccination
...
Patients developing Neuro-PASC after BTI have a higher burden of comorbidities than those with PVI
...from a scientific perspective, it would be interesting to see what the inclusion of zero vaccines would look like in this study. That vector never seems to be included in any tests regarding COVID and the impact on a body of subjects.
I don't care about the politics and such about vaccine vs no vaccine...we have 3 groups that should be studied: the two in the study and the third just mentioned.
Comment by AcornAl at 09/01/2025 at 10:14 UTC
15 upvotes, 0 direct replies
Briefly, all patients must have had COVID-19, confirmed by positive SARS-CoV-2 PCR or positive rapid antigen testing, and/or positive serology for SARS-CoV-2 prior to vaccination. Additionally, patients must have had at least 6 weeks of persisting neurologic symptoms since confirmed COVID-19 infection.
So this study is only looking at patients with neurologic symptoms.
I assume the pathway to having persisting neurologic symptoms is the same irrespective of being vaccinated or unvaccinated, so nothing too surprising here unless I'm missing something?
Similar to being hospitalised with covid, the ICU/death rates of the unvaccinated and vaccinated are fairly similar after being admitted to hospital, *but far less vaccinated cases end up in hospital* so there is a far lower ICU/death rate in the vaccinated overall.
While vaccination decreases the severity of acute COVID-19 and the rate of hospitalization and death, the sobering conclusion of our study is that vaccination prior to infection did not alter the subsequent neurologic manifestations of long COVID in our clinic population.
The vast majority of cases in the study had pre-vaccination infections (73%).
The current vaccination rate in the US is 83% of all adults (Pulse survey[1]), or 17% are unvaccinated. Assuming the study was only on adults, *the unvaccinated are overrepresented by a factor of four*. That's a more sobering fact imho.
As an aside, this back of the envelope calculation likely overrepresents the benefits of vaccination, as many of the post-vaccination infections would have been Omicron for example, but as far as the data from this study shows, being vaccinated helps significantly to lowers the absolute risk.
Comment by SvenAERTS at 10/01/2025 at 05:00 UTC
1 upvotes, 0 direct replies
Vaccination did not reduce the severity of the neurological manifestation?!
If the body can nip eg the re-activated herpes dormant viruses quicker the neurological effects should be less, right?
Comment by [deleted] at 09/01/2025 at 07:07 UTC
-3 upvotes, 0 direct replies
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